Download PDF by Kenneth L. Kirk: Biochemistry of Halogenated Organic Compounds

Environmental Studies

By Kenneth L. Kirk

Biochemistry of Halogenated natural Compounds has been written as a basic reference resource for researchers in different comparable parts, together with natural chemists, medicinal chemists, pharmacologists, toxicologists, and scientific researchers. the advance of halogenated compounds as medicinal brokers and pharmacological instruments and the attention-grabbing biochemi­ cal strategies which have been came upon and studied utilizing those analogues have generated super lively components of analysis and an important quantity of literature. hence, halogenated natural compounds pervade each point of biochemistry, a truth made obvious by way of the varied reports and monographs to be had on person topics-halogenated nucleosides, halogenated carbohydrates, etc. Given the amount of fabric already written on those subject matters, a few of which fabric is kind of present, it'd be requested no matter if a one-volume overview of those topics turns out to be useful, or attainable. Having now accomplished this paintings, i think the reply to either questions is an emphatic certain. There are attention-grabbing tales to be similar in every one zone, and, the place acceptable, i've got tried to strengthen those themes . from a historic viewpoint. for instance, the invention of the anticancer job of fluorouracil, the unraveling of the different mechanisms of its motion, and the advance of a bunch of later generations of anticancer and antiviral brokers in accordance with the father or mother fluoro-, iodo-, bromo-, and trifluoromethylpyrimidines have been, and are, contributions of significant significance to clinical science.

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Branched chain ct-ketoacid dehydrogenase and pyruvate dehydrogenase activity in isolated rat pancreatic islets, Horm. Metabol. Res. 20:317-322. , 1972. Some metabolic aspects of fluoroacetate especially related to fluorocitrate, in Ciba Foundation Symposium: Carbon-Fluorine Compounds: Chemistry, Biochemistry, and Biological Activities, Elsevier, Amsterdam, 1972, pp. 55-76. Plishker, G. , 1985. Iodoacetic acid inhibition of calcium-dependent potassium effiux in red blood cells, Am. J. Physiol. 248:C419-C424.

Phosphoenol-3-bromopyruvate. A mechanism-based inhibitor of phosphoenolpyruvate carboxylase from maize, J. Bioi. Chem. 257:14603-14605. Patel, S. , and Walt, D. , 1987. Substrate specificity of acetyl coenzyme A synthase, J. BioI. 262:7132-7134. Paulsen, R. , 1987. An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: The use of fluorocitrate, J. Neurochem. 48:1377-1385. , and Harris, R. , 1984. Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain ct-ketoacid dehydrogenase in vitro and in perfused rat heart, Arch.

Monti, C. , Preston, R. , and Glusker, 1. , 1983. Intermolecular interactions of the C-F bond: The crystallographic environment of fluorinated carboxylic acids and related structures, J. Am. Chem. Soc. 105:3206-3214. , 1984. A new reaction useful for chemical cross-linking between nucleic acids and proteins, FEBS Lett. 166:194-198. , 1973. Affinity labeling of aspartate aminotransferase isozymes by bromopyruvate, J. BioI. Chem. 248:82-90. O'Leary, M. , 1982. Phosphoenol-3-bromopyruvate. A mechanism-based inhibitor of phosphoenolpyruvate carboxylase from maize, J.

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