Bleomycin: Chemical, Biochemical, and Biological Aspects: by Sidney M. Hect (auth.), Sidney M. Hect (eds.) PDF

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By Sidney M. Hect (auth.), Sidney M. Hect (eds.)

This publication documents the court cases of a joint U.S.-Japan symposium at the chem­ istry, biochemistry, and biology of bleomycin, an antitumor antibiotic proven to be potent therapeutically opposed to, eg, squamous mobilephone carcinomas, Hodgkin's lymphoma, and testicular tumors. a number of vital and formerly unreported observations have been awarded and the prestige of experimental paintings within the usa and Japan used to be reviewed; a precis and interpretation of the medical shows on the assembly has been ready by way of the editor and is incorporated because the first contribution during this quantity. as well as the symposium contributions, an experimental part has been incorporated on the finish of the ebook facing useful tools for the fractiona­ tion, amendment, and assay of bleomycin. it really is was hoping that this part will facilitate development during this zone of clinical recreation. The symposium from which this booklet is derived used to be equipped through Drs. Umezawa, Takita, and Hecht and supported financially by way of the nationwide technological know-how beginning, the nationwide melanoma Institute, and the Japan Society for the advertising of technology. S. M. Hecht v Contents prestige reviews precis of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin stories. H. UMEZAWA ................... , 24 assessment of the Structural reviews on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . artificial and Biosynthetic reports experiences at the overall Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... forty eight an artificial method of the Pyrimidine Moiety of Bleomycin.

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Extra info for Bleomycin: Chemical, Biochemical, and Biological Aspects: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978

Example text

65, 371 (1975). 36 H. Umezawa 41. W. E. G. Miiller, H. I. Rohde, R. Steffen, A. Maidhof, and R. K. Zahn, Cancer Lett, 1. 127 (1976t 42. Y. Yagoda and H. Krakoff, Fundamental and clinical studies on bleomycin. GANN Monograph on Cancer Research, No. 19 (Japanese Cancer Association), University of Tokyo Press, pp. 255-268 (1976). 43. T. Ichikawa, A. Matsuda, K. Yamamoto, M. Tsubosaki, T. Kaihara, K. Sakamoto, and H. Umezawa,J. Antibiot. (Tokyo), Ser. A, 20,149 (1967). 44. H. Umezawa, T. Takeuchi, S.

Asama, H. Tsukiura, T. Naito, and H. Kawaguchi, J. Antibiot. (Tokyo), 30,789 (1977). Studies on the Total Synthesis of Bleomycin SIDNEY M. HECHT, DONALD 1. BURLETT, YOSHITAKA MUSHIKA, YASUHISAKuRODA, AND MARK D. LEVIN Several practical rewards may be expected to derive from the development of a workable total synthesis of bleomycin. In addition to permitting the direct verification of the proposed structure (which has been revised during this meeting by Dr. Umezawa and his co-workers) and hopefully extending the repertoire of available synthetic techniques, bleomycins of modified structure should facilitate the study of the mechanism of action of the drug and thus help to defme the structures of analogs that may have improved anticancer activity.

Fig. 1. Behavior of bleomycin in vivo. Advances in Bleomycin Studies 33 ratio, and this reaction is inhibited by N-ethylmaleimide. Cuprous ion is easily converted by oxygen to cupric ion which readily binds to copper-free bleomycin. Therefore, in removing cupric ion from bleomycin copper complex, cuprous ion must be captured by some cellular component. As a result of this study a cuprous ion-binding protein was found in cells for the first time. AH66 rat hepatoma cells were used in the experiment (47).

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