Canine Parvovirus: A New Pathogen - download pdf or read online

Nonfiction 8

By Dr. Cherelyn Vella, S. W. Ketteridge (auth.), Dr. Cherelyn Vella, S. W. Ketteridge (eds.)

Canine parvovirus (CPV), a brand new virus of the Canidae first seemed throughout the Seventies, yet affliction because of this virus was once now not stated till 1978. Then inside of a couple of months the virus crossed nationwide and continental limitations inflicting excessive fatality in pup populations. the same trend of transmission used to be noticeable in sylvatic canine yet an infection was once mostly subclinical. among 1979 and 1981 CPV used to be changed around the globe by means of an antigenic variation precise CPV-2a. The epidemiological good thing about this variation over CPV isn't really understood. CPV is a brand new pathogen of canine that has attracted a powerful physique of study. even if features of the biology of this virus stay uncertain, no longer least of that's the questionof its attainable foundation. This e-book provides an up-to-the-minute and accomplished assessment of the usual heritage of CPV and its keep watch over through prophylactic vaccination. specific awareness is paid to the ideas used to ascertain the connection among CPV and different parvoviruses. CPV is believed to be a variation of the virulent cat virus FPV (feline parvovirus) and at the least another variation is understood MEV (mink enteritis virus). Theories at the genesis of CPV are mentioned. An try to correlate the proof and an hypothetical mechanism wherein this type of variation might have been chosen is obtainable. This speculation is complemented through serological evidenceof CPV seroconversion in clinically basic canines a few years ahead of the virulent pandemic. Many animal parvoviruses are recognized and in 1989/1990, at least 6 new viruses have been defined. CPV can have arisen from an FPV vaccine pressure. using transformed stay vaccines for the regulate of those viruses is puzzled and substitute suggestions mentioned. A consise bankruptcy on human parvoviruses describes the ever expanding position of B19 in human disorder, together with that of an opportunistic pathogen in AIDS patients.

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Vet Rec 83:653-655 Ferm VH, Kilham L (1964) Congenital anomalies induced in hamster embryos with H-l. Science 145:510--511 Fletcher KC, Eugster AK, Schmidt RE, Hubbard GS (1979) Parvovirus infection in maned wolves. J Am Vet Med Ass 175:897-900 Florent G (1986) Enzyme-linked immunosorbent assay for single serum diagnosis of canine parvovirus disease. Vet Rec 119:479-480 Flower RLP, Wilcox GE, Robinson WF (1980) Antigenic differences between canine parvovirus and feline panleucopenia virus. Vet Rec 107:254-256 Foni E, Gualandi GL, Capucci L (1989) Characterization of a parvovirus isolated from a pig foetus.

Assuming that the SN test is more specific, then this could point to some antigenic diversity in these cases. These authors therefore argue that the three dogs in question were not infected with CPV, but some other related parvovirus that was not transmissible from dog to dog. This raises the possibility that the Belgian workers may similarly have been measuring cross-reactivity of a related parvovirus other than CPV. The only novel point in this interpretation is the proposal that CPV has evolved from an FPV vaccine strain by undergoing reversion to virulence on passage through cats and subsequently dogs.

Similarly, CPV-2a replaced CPV in coyote populations in the United States of America between 1980 and 1981. The differences revealed by mAbs in virion capsid proteins are consistent with studies on the structure of the genome of parvoviruses using restriction endonuclease mapping and sequence analysis of replicative form DNA. 2 Restriction Endonuclease Analysis and Sequence Analysis of Parvovirus DNA Double-stranded replicative form (RF) parvovirus DNA can be analysed using restriction endonuclease enzymes.

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