Case Files- : Microbiology, Second Edition - download pdf or read online

By Eugene C. Toy, Cynthia R. Skinner DeBord

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Burgdorferi DNA. Borrelia burgdorferi is difficult to grow in culture, requiring complex culture media and a microaerophilic environment. It is also difficult to visualize under light microscopy, but can be seen under darkfield microscopy or when stained with Giemsa or silver stains. Treatment and Prevention Initial stages of infection with B. burgdorferi can be effectively treated with doxycycline or amoxicillin, while later stages of disease are better treated with penicillin G or ceftriaxone.

The cultures of the purulent drainage reveal B. fragilis. ◆ Characteristics on gram staining: Bacteroides fragilis appears encapsulated, with irregular staining, pleomorphism, and vacuolization. ◆ Primary mechanisms of resisting phagocytosis: The capsular polysaccharide and succinic acid production. CLINICAL CORRELATION Bacteroides fragilis is one of the most clinically significant anaerobic organisms. It is part of the normal flora of the gastrointestinal (GI) tract and causes clinical infections when it escapes from this environment following surgery, traumatic bowel perforation, or other diseases, such as diverticulitis.

Itraconazole has been associated with heart failure when used to treat onychomycosis and, therefore, should not be used in patients with ventricular abnormalities. A common side effect of griseofulvin is hypersensitivity. Because of renal toxicity, amphotericin B is often used to initiate a clinical response before substituting a continuing maintenance dose of an azole. 24 CASE FILES: MICROBIOLOGY REFERENCES Gale EF, Cundliffe E, Reynolds PE, et al. The Molecular Basis of Antibiotic Action, 2nd ed.

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