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By Marie Siewierski
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Extra info for Determination and Assessment of Pesticide Exposure: Working Conference Proceedings
A d d i t i o n a l s t u d i e s may be c u n d u c t e d t o d e t e r m i n e , f o r example, dermal a b s o r p t i o n . Overall hazard i s e v a l u a t e d t h r o u g h c o n s i d e r a t i o n o f t o x i c i t y , f a t e , and e x p o s u r e . Safe f i e l d use practices with pesticides r e f l e c t a l l these evaluations. INTRODUCTION The t i t l e of t h i s p a p e r i l l u s t r a t e s a few p o i n t s . The l a s t word i s p e s t i c i d e s . A p r a c t i c e i s d e f i n e d as "a r e p e a t e d o r customary a c t i o n .
In the case or m e c h a n i c a l l y h a r v e s t e d c r o p , a t t e n t i o n must b e d i r e c t e d t o tlie e x p o s u r e by s o i l o r s o i l - b o r n r e s i d u e s t o f o o d p r o c e s s i n g p l a n t p e r s o n n e l who must IiandLe rind c l e a n produce a s i t a r r i v e s . We g e n e r a l l y c o n s i d e r tlie consumption of t r c a t e d m a t e r i a l o u t s i d e tlie a r e a o f e x p o s u r e s t u d i e s , s i n c e food m a t e r i a l s a r e I l i g h l y r e g u l a t e d by tlie EPA and FDA.
Meanwhile, subchronic toxicity studies lead up to lifetime feeding studies which determine the chronic toxicity and cancer-causing potential of the compound. tional studies determine the effects of a compound on reproductive potential. tology studies determine the potential of a compound to cause birth defects. genicity studies detect interaction with DNA. AddiTernMuta- These specialized tests a r e requlred for full pesticide registration, under EPA's administration of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).