New PDF release: Diagnosis and management of chronic open angle glaucoma and


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Extra resources for Diagnosis and management of chronic open angle glaucoma and ocular hypertension:Methods, Evidence & Guidance

Example text

The GDG was convened by the NCC-AC and chaired by Mr. John Sparrow in accordance with guidance from the National Institute for Health and Clinical Excellence (NICE). The group met every 6-8 weeks during the development of the guideline. At the start of the guideline development process all GDG members declared interests including consultancies, fee-paid work, share-holdings, fellowships and support from the healthcare industry. At all subsequent GDG meetings, members declared arising conflicts of interest, which were also recorded (Appendix B).

3). Included papers were reviewed by a health economist. In the evidence tables, costs are reported as in the paper. However, where costs were in a currency other than pounds sterling, the results were converted into pounds sterling using the appropriate purchasing power parity for the study year. We have included studies from all over the world in our review, however, we use overseas studies with caution since resource use and especially unit costs vary considerably. Particular caution is applied to studies with predominantly private health insurance (For example, USA or Switzerland) where unit costs may be much higher than in the UK and to developing countries where costs may be much lower.

Fixed-effects (MantelHaenszel) techniques were used to calculate risk ratios (relative risk) for the binary outcomes: number of patients with visual field progression, number of patients with an acceptable or unacceptable IOP or numbers of adverse events, and the continuous outcome for change in IOP from baseline was analysed using an inverse variance method for pooling weighted mean differences. When combining data for number of patients with visual field progression we acknowledge that there may be limitations as it is difficult to standardise this outcome when each study has defined and measured visual field progression differently.

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