Diagnosis and management of soft tissue sarcoma - download pdf or read online


By Murray F. Brennan

Management of sentimental Tissue Sarcoma addresses the prognosis and most sensible present administration of grownup gentle tissue sarcomas. Edited via global popular specialists, this e-book delineates and discusses every one diverse sarcoma subtype separately. either scientific and molecular diagnoses are addressed, and tumor histopathology is hired because the foundation of remedy techniques together with surgical procedure, radiation remedy, systemic remedy and novel therapeutics.

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Malignant peripheral nerve sheath tumor (MPNST) (malignant schwannoma, neurofibrosarcoma) (a) Malignant triton tumor (MPNST with rhabdomyosarcoma) (b) Glandular MPNST (c) Epithelioid MPNST 2. Malignant melanocytic schwannoma 3. Primitive neuroectodermal tumor (PNET) and extraskeletal Ewing’s sarcoma 4. Malignant granular cell tumor XI. Extraskeletal cartilaginous and osseous tumors A. Benign tumors 1. Panniculitis ossificans and myositis ossificans 2. Fibro-osseous pseudotumor of the digits 3. Fibrodysplasia (myositis ossificans progressiva) 4.

8 34 Diagnosis and Management of Soft Tissue Sarcoma months (4–181 months). Local recurrence was not dependent on site or size or a positive resection margin. Despite having a positive resection margin, only 22% developed local recurrence, compared with 24% of patients who developed a local recurrence in the absence of positive microscopic margins. Radiation has been utilized selectively in patients, but it does not appear to be an independent factor in our analysis of risk of local recurrence.

G. 3. 3 Immunohistochemical markers in the differential diagnosis of sarcoma. Vimentin Keratin or S-100 Desmin, Myoglobin/ CD34 CD31 013 HMB45 EMA actin myogenin antigen Carcinoma Leiomyosarcoma Rhabdomyosarcoma MPNST Synovial sarcoma Angiosarcoma PNET/Ewing’s sarcoma Clear cell sarcoma Alveolar soft part sarcoma Epithelioid sarcoma Soft tissue myxoid sarcoma +/– + + + + + + + + + + + + + + + + + +/– + + + + + The pathologist should be prepared to process tissue from selected cases for electron microscopy, cytogenetic studies, or molecular analysis, provided that certain diagnoses are considered by the clinician, the diagnostic biopsy is obtained appropriately, and the clinician and pathologist communicate before the biopsy is performed to ensure that the pathologist is alerted to the need for such procedures.

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