Download e-book for iPad: Drugs of Abuse: Pharmacology and Molecular Mechanisms by Sherrel Howard
By Sherrel Howard
Introducing the fundamental ideas of neuroscience and pharmacology, The Pharmacology of substances of Abuse educates scholars at the chemical mechanisms and physiological results of often abused medicinal drugs. overlaying stimulants and depressants, chapters conceal neurophysiology and neurochemistry in addition to the cultural context and background of varied periods of stimulants. Designed as a source for undergraduate scholars majoring in neuroscience, physiological psychology, biology, body structure, and biochemistry, this worthwhile textbook offers up to date assurance of medical neuroscience whereas instructing scholars at the physiological and mental results of drug use.
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Additional info for Drugs of Abuse: Pharmacology and Molecular Mechanisms
There are known drugs that can interfere with the storage and transport process, such as reserpine. Reserpine acts by depleting the vesicles of the stores of DA, NE, and 5-HT. Metabolism The catecholamines, DA, and NE are metabolized primarily by two enzymes, monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). After release, DA is taken up into the nerve terminal by the Uptake I carrier. 2). In most neurons, information is transmitted chemically by the neurotransmitter. The basic steps in the synthesis and release of a neurotransmitter are essentially the same for both the catecholamines (DA and NE) and the indolamines (5-HT).
Tyrosine hydroxylase requires several cofactors. Specific cofactors required by tyrosine hydroxylase are as follows. 1. Molecular O2 2. Fe + + 3. 1 Synthetic pathway starting with the precursor L-tyrosine to form DA and norepinephrine. Inhibition of tyrosine hydroxylase is one effective way to decrease the concentration of DA or NE in the brain or NE in peripheral sympathetically innervated nerves. Additionally, amino acid analogs or catechol derivatives will also inhibit tyrosine hydroxylase. Dihydroxyphenylalanine Decarboxylase Dihydroxyphenylalanine (DOPA) decarboxylase does not demonstrate a high degree of specificity and will act on many L-aromatic amino acids.
Children suffering from ADHD tend to have difficulty focusing for longer periods of time and often display agitated or aggressive behavior. Amphetamine in the ADHD patient increases the ability to focus and pay attention and decreases agitated behavior. In a normal well-rested child, amphetamine acts as a stimulant and may increase agitated behavior. This effect is often called a paradoxical response, because amphetamine is a stimulant in normal children, and calming in the ADHD child. Physical and mental fatigue is reduced by amphetamine and many studies have shown that amphetamine improves performance in fatigued subjects.