New PDF release: Early Diagnosis and Treatment of Cancer Series: Ovarian

Diagnosis

By Robert Bristow MD, Deborah Armstrong MD

Every one quantity within the Early Detection and therapy of melanoma sequence is jam-packed with useful, authoritative details designed to hide the whole diversity of diagnostic tactics, together with pathologic, radiologic, bronchoscopic, and surgical elements. one can ensure the most secure, shortest, least invasive approach to achieve a correct analysis; degree the sickness; and select the simplest preliminary remedy for early phases. in keeping with present facts within the literature, authors offer medical, hands-on instruments that will help you make trained judgements on accurately what checks and imaging reviews are had to diagnose and degree every one form of melanoma. functional, authoritative, and highly-illustrated, this quantity within the fresh Early Detection and remedy of melanoma sequence covers present protocols and the most recent advances in diagnostic imaging and molecular and serologic markers for ovarian melanoma. follow specialist suggestion at the most sensible "next-step" plan for various displays and information for much less invasive protocols. Get scientific, hands-on instruments that can assist you make expert judgements on accurately what checks and imaging stories are wanted for exact analysis and staging. transparent figures, tables, and containers illustrate step by step care of the entire diversity of difficulties encountered. higher deal with your sufferers with procedural videos and extra at the incorporated CD-ROM. The small measurement and handy structure make this an amazing buy for diagnostic reference.Outlines the stairs after prognosis to steer you thru formulating a therapy or sufferer care plan.Emphasizes very important points-such as vaccines, paracentesis, and laparoscopic strategies for staging-with "key issues" packing containers first and foremost of every bankruptcy and pedagogic good points throughout.Summarizes the method of properly diagnosing and staging melanoma in a logical, nearly algorithmic, strategy for simple reference.Discusses the therapy of early-stage sickness so that you have transparent suggestions for care.Complements the systems defined within the textual content with full-color pictures and line drawings to augment your knowing of the material.Features a CD-ROM exhibiting movies of diagnostic techniques, in addition to the entire photographs, tables, and drawings from the textual content that will help you higher deal with your sufferers.

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Extra info for Early Diagnosis and Treatment of Cancer Series: Ovarian Cancer: Expert Consult

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Cancer Cell 11:321–333, 2007. 55. Tsuchiya A, Sakamoto M, Yasuda J, et al: Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. Am J Pathol 163:2503–2512, 2003. 56. Hough CD, Sherman-Baust CA, Pizer ES, et al: Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res 60:6281–6287, 2000. 57. Francis-Thickpenny KM, Richardson DM, van Ee CC, et al: Analysis of the TGF-beta functional pathway in epithelial ovarian carcinoma.

High-grade serous carcinoma (HGSCA) is characterized by very high frequency of mutations in p53, amplifications in cyclin E, AKT, and PI3CA loci. Low-grade serous carcinoma (LGSCA) harbor activating mutations in KRAS, BRAF, or ERRB2. Endometrioid carcinoma (EMCA) contains mutations in β-catenin and PTEN. Although the molecular genetic changes in clear cell carcinoma (CCCA) have not been extensively studied, mutations in PI3CA have been detected in approximately 20% of cases. Mucinous carcinoma (MCA) is characterized by mutations in KRAS in most cases.

46. 47. 48. 49. 50. 51. 52. 53. copathologic and molecular study of two cases. Int J Gynecol Pathol 21:268–272, 2002. Kounelis S, Jones MW, Papadaki H, et al: Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. Hum Pathol 29:82–87, 1998. Abeln EC, Smit VT, Wessels JW, et al: Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed mullerian tumours. J Pathol 183:424–431, 1997.

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