Effects of Antidepressants by R. Lu PDF

Addiction Recovery

By R. Lu

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2002). 5, 15 and 30 mg/kg) were administered immediately after IA training. Subjects were tested for avoidance twenty four hours later. 5 and 30 mg/kg in CD1 females. The sex differences observed were limited to a slightly stronger effect of amitriptyline on IA in males than in females. These results indicate that acute amitriptyline administration produces retrograde amnesia in a IA task, which does not seem to be mediated by anxiolytic effects: when CD1 mice explored an elevated plus-maze during a five-minute period forty-five minutes after injection amitriptyline had no effect on anxiety (percentage of open arm entries) and induced a dose-dependent impairment of activity (number of closed arm entries), which did not affect IA, as the drug was administered after training (see conclusions regarding pharmacokinetic rationale).

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