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Nonfiction 8

By Basil S. Hetzel (auth.), G. Robert DeLong, Jacob Robbins, Peter G. Condliffe (eds.)

This quantity includes the complaints of a convention held on the nationwide Institutes of well-being in Bethesda on March 21-23. 1988. together subsidized by way of the foreign Council for regulate of Iodine Deficiency issues (ICCIDD) and the Fogarty foreign middle of the nationwide Institutes of overall healthiness. a number of subject matters converged to make this assembly well timed. the 1st is an expanding understanding of iodine deficiency problems as a world-wide challenge of public wellbeing and fitness and a preventable reason for psychological deficiency. and as a subject matter of clinical attempt. elevated curiosity in those difficulties owes greatly to accessibility to distant and lower than­ constructed parts of the realm the place iodine deficiency persists. as with all topic. larger scrutiny yields unforeseen complexity and curiosity. it's precise that provision of iodine. usually as iodized salt, is the mandatory and enough preventative for iodine deficiency problems. with no together with endemic cretinism. This provision is a governmental, fiscal and social challenge. except this, even if, the medical and scientific challenge of iodine deficiency and its impression on mind improvement and serve as is certainly one of nice curiosity and significance for developmental neurology and psychology. although the explicit preventative agent is understood, we don't absolutely comprehend the neurobiological questions raised.

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M. Landow, Tracer kinetic model of blood brain barrier transport of plasma protein-bound ligands. Empiric testing of the free hormone hypothesis, J Clin Invest 74:745-752 (1984). 9. J. L. Johnson, Possible significance of multiple transport proteins for the thyroid hormones, in: "Free Hormones in Blood", A. P. , Elsevier Biomedical Press, Amsterdam (1982) • 10. J. C. ' 11. ·C. K. C. , Munksgaard, Copenhagen (1971). 48 12. J. E. RaIl, Proteins associated with the thyroid hormones, Physio1 Rev 40:415-489 (1960).

In fibroblasts, this has been demonstrated directly by fluorescence microscopy34 showing that rhodaminelabeled T3' after attaching to the cell surface, moves into coated pits and then enters the cytoplasm via coated vesicles. This energy-dependent phenomenon can be blocked by endocytosis inhibitors such as monodansylcadaverine (MDe). We have shown that MDe also inhibits T3 and T4 uptake by mouse neuroblastoma and human medulloblastoma and glioma cells. Some of these data are given in Fig 4. They indicate that thyroid hormone uptake by cells of the eNS probably involves a receptor-medjated endocytosis mechanism.

Krenning and R. Docter, Plasma membrane transport of thyroid hormone, in: "Thyroid Hormone Metabolism", G. , p. 107-131 (1986) . 49 32. A. Pontecorvi, M. Lakshmanan and J. Robbins, Intracellular transport of 3,5,3 1 -triiodo-L-thyronine in rat skeletal myoblasts, Endocrinology 121:2145-2152 (1987). 33. S-Y. Cheng, Characterization of binding and uptake of 3,3 1 ,5-triiodothyronine in cultured mouse fibroblasts, Endocrinology 112:1754-1762 (1983). 34. S-Y. R. Maxfield, J. C. Willingham and I. Pastan, Receptor mediated uptake of 3,3 1 ,5-triiodo-L-thyronine by cultured fibroblasts, Proc Natl Acad Sci USA 77:3425 (1980).

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