Download e-book for kindle: Medical Toxicology: Proceedings of the 1991 EUROTOX Congress by D. Kello (auth.), H. M. Bolt, F. A. de Wolff, P. Th.


By D. Kello (auth.), H. M. Bolt, F. A. de Wolff, P. Th. Henderson (eds.)

The e-book includes reports and posters of the thirty first Congress of the EUROTOX (Maastricht 1991). - Forensic Toxicology - Drug Toxicology - Environmental Toxicology

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Additional info for Medical Toxicology: Proceedings of the 1991 EUROTOX Congress Meeting Held in Masstricht, September 1 – 4, 1991

Sample text

80; bicarbonate = 6 roMol/l; chlore=126 roMol/l). Treatment included infusion of bicarbonate, exchange transfusion and several hemodialyses. Before admission, the patient had been hospitalized in a surgical unit because of pancreatitis and treated with arginine chlorhydrate infusions for 15 days and penicillin infusions at a dose of 50 M daily for 8 days. Specific antipenicillin antibodies were detected in the serum by the indirect Coombs test. The final diagnoses were: hyperchloremic acidosis due to arginine chlorhydrate overdose, immunoallergic hemolysis and nephropathy due to penicillin.

A possibility is that interaction between red cells and the column resulting in release of ADP from red cells (Salzmann 1977), induces platelet activation followed by a state of refractoriness of these platelets (Peerschke 1985). Further studies are required to clarify the cause of haemoperfusion related platelet function disturbance. However, considering the slight extent of inhibition of platelet aggregation, its clinical importance is probably limited. Which factors are responsible for the transient character of the proces of platelet sequestration?

Role of ffbrinigen in activation of platlets by artificial surfaces. Ann NY Acad Sci 1987;516:184-96. 33. 34. Sanders JS, Ferguson DW. Profound sympathicoinhibition complicating hypovolemia in humans. Ann Int Ned 1989;111:439-41 Sangster B, Heyst ANP van, Sixma JJ. The influence of haemoperfusion on haemostasis and cellular constituents of the blood in the treatment of intoxications. Arch Toxicol 1981;47:269-78. 35. Secher NH, Bie P. Bradycardia during reversible haemorrhagic shock-a forgotten observation?

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