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Allied Health Services

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In this case, the immobili‐ zation assists native microbes in improving their biosorption capacity. The biosorption efficiency was reportedly highly time and pH dependent and affected by initial Pb(II) con‐ centration [118]. 3. Targeted drug delivery using magnetic nanoparticles There are many advantages when talking about targeted drug delivery systems based on magnetic nanoparticles. Compared to other conventional drug carriers, magnetic nanoparti‐ cles have a better retention ability and are therefore promising simulative carriers that can transport a drug to the desired place in the body.

GA and EDC are because of their functional group (aldehyde group) mostly covalently cross‐linked to magnetic nanoparticles and enzymes/proteins due to their interaction with both functional groups (Figure 3). However, in some cases, the presence of a coupling agent can also cause conformational changes in proteins, which can result in a decrease of enzyme activity. Figure 3. Covalent immobilization of the enzyme. There are many researches performed, where enzymes were covalently immobilized onto iron magnetic nanoparticles.

Toxicol. 172 (2016) 9–20. aquatox. 013. [13] M. Leitgeb, K. H. Podrepšek, A. Hojski, A. Crnjac, Z. Knez, Toxicity of magnetic chitosan micro and nanoparticles as carriers for biologically active substan‐ ces, Acta Chim. Slov. 61 (2014) 145–152. [14] G. Liu, J. Gao, H. Ai, X. Chen, Applications and potential toxicity of magnetic iron oxide nanoparticles, Small. 9 (2013) 1533–1545. 201201531. [15] C. Gerday, M. Aittaleb, M. ‐P. Chessa, P. Claverie, T. , Cold‐ adapted enzymes: From fundamentals to biotechnology, Trends Biotechnol.

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