Read e-book online Minimal Neoplasia: Diagnosis and Therapy PDF


By L. G. Koss (auth.), Professor Dr. Ekkehard Grundmann, Professor Dr. Lutwin Beck (eds.)

Minimal neoplasia should be outlined as a small melanoma that has stepped forward past its web site of basic starting place into the encircling tissue, yet that has now not but reached the level of deeper invasion or metastasization. the fundamental rules of this minimum melanoma are awarded in chapters on molecular, organic and experimental elements, and, particularly, at the medical manifestations in quite a few organs: preleukemia, incipient lymphoma, and minimum carcinomas of the uterine cervix, breast, thyroid, larynx, lung, prostate, abdominal and colon. A separate bankruptcy is dedicated to cryptic gliomas. the most recent morphological tools together with cytology, early medical diagnostics and, specifically, radiodiagnostics, are thought of. The reader can anticipate up to date information regarding advised prognosis of the very early manifestations of melanoma, including inferences on remedy, which, in particular in tumors of the uterine cervix, breast and thyroid, differs significantly from the therapy of complex neoplasia.

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Extra resources for Minimal Neoplasia: Diagnosis and Therapy

Sample text

It can be concluded that an impaired repair of the promutagenic 06-alkylguanine does not belong to the characteristics of the target cell for liver carcinogenesis, but that the proximity of early S phase might indeed be a critical determinant of the transformation probility of hepatocytes. An essential prerequisite for the expression of the transformed phenotype is proliferative potential. Initiated hepatocytes are endowed with a proliferative advantage over normal hepatocytes. This leads to the formation of clones of enzyme-aberrant cells in the liver.

All cells of the hyperdiploid line show a quadruplication of chromosome 3, and the chromosomes 7 and 12 are present in tri- or quadruplicates (Holecek and Rabes 1986). Consistent translocations and deletions in several other chromosomes are further in support of the assumption that the cell line is a tumorigenic hepatocellular clone which had originated by clonal selection from preneoplastic cells. This clone shows aberrations from the normal hepatocellular genotype: DNA of the tumorigenic cell line contains an increased number of copies of the H-ras gene, most of them forming a separate band in the Southern blot, indicating a translocation to another part of the genome.

1973; Lohe 1978; Lohe et al. 1978). For microcarcinoma of the cervix, for example, a tumor volume of 500 mm 3 has been reported. However, it has been demonstrated that this tumor volume is not applicable to the so-called microcarcinoma of the vulva (Friedrich and Wilkinson 1986). Another problem derives from the fact that the above-mentioned measurements do not consider whether the tumor grew uni- or multifocally. 5% of cases of Fig. 1. Depth of invasion should be measured from A, the top of the most dermal papilla, rather than B, the inconstant surface, or C, the deepest ridge Recent Results in Cancer Research, Vol.

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