Molecular Diagnosis and Treatment of Melanoma by John M. Kirkwood PDF


By John M. Kirkwood

Facilitating efforts to avoid cancer development, this up to date reference provides the newest advances within the pathology, molecular biology, and remedy of cancer in early, high-risk, and complicated phases. Discusses progress components, cytokines, receptors, oncogenes, tumor suppressor genes, adhesion molecules, and proteases in cancer and examines the precise use of interferon adjuvant treatment! Written through top specialists from the USA and Europe, Molecular analysis and therapy of cancer · information the preclinical and scientific foundation for brand new vaccines in keeping with gangliosides and peptides · explains the jobs of chemotherapy and radiosurgery · reports the molecular positive factors of cancer and precursor cells · describes the occasions interested by induction and upkeep of antitumor T-cell reaction and diverse get away mechanisms from immune attractiveness · analyzes melanotic and dysplastic nevi · explores the potential for vaccines that result in antibodies in immunotherapy and vaccines in high-risk cancer · summarizes cytotoxic chemotherapy in treating metastatic cancer · elucidates whole-brain radiotherapy, surgical resection, and stereotactic radiosurgery in coping with cancer mind metastasis · and extra! Containing key bibliographic citations for extra in-depth learn of specific subject matters, Molecular prognosis and remedy of cancer is a superb source for oncologists, dermatologists, molecular and cellphone biologists, immunologists, pathologists, pharmacologists, toxicologists, interns, citizens, fellows, and graduate and scientific institution scholars in those disciplines.

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The CD3 complex consists of six invariant chains: CD3g, CD3d, two copies of CD3e, and a CD3z homodimer (23). In about 20% of chains, the z homodimer may be substituted by a z/h heterodimer (27). No recognizable enzymatic domain has been identified in any of these chains, but they contain the antigen-recognition activation motif (ARAM) or the tyrosine-based activation motif (TAM) that has been demonstrated to have signaling function (28). Following phosphorylation by protein tyrosine kinases (PTK), ARAMs interact with the antigen receptor and thereby recruit to it the Syk family tyrosine kinases p72syk and z-associated protein-70 (ZAP-70) (29,30).

Over the past several years, the study of growth requirements for malignant melanomas and normal melanocytes has also focused extensively upon the analysis of receptors to which growth factors/cytokines have to bind in order to initiate signal transduction and thus induce cell proliferation. For example, like the ligand bFGF, one of its receptors, fibroblast growth factor receptor 1 (FGFR-1) (10), is expressed at very low levels in normal melanocytes but at high levels in Page 7 primary and metastatic melanomas (11).

Therapeutic discussions have risen to the masthead only recently, and the degree to which they may figure into future similar volumes will doubtless continue to increase as the work described in this volume bears results. JOHN M. KIRKWOOD Page vii CONTENTS Preface iii Contributors xi Part I. Molecular Features of the Biology of Melanoma 1 Molecular Features of Melanoma Progression Ulrich Rodeck and Dorothea Becker 3 2 Immunologic Features of Progression in Melanoma Jürgen C. Becker and Eva-Bettina Bröcker 25 Part II.

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