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Diagnosis

By D. H. Wright (auth.), Professor Dr. med. Volker Diehl, Professor Dr. med. Michael Pfreundschuh, Dr. med. Dipl. Phys. Markus Loeffler (eds.)

In the sphere of Hodgkin's lymphoma, many new facts were accrued over the past decade either at the telephone of starting place of this sickness and on more desirable remedies to therapy the vast majority of pa­ tients even within the complex levels. for this reason, it sort of feels to be justi­ fied to bring together those new facts in a unique quantity of modern Re­ sults in melanoma examine. This quantity summarizes the contribu­ tions provided on the First foreign Symposium on Hodgkin's illness that came about in Cologne (FRG) on October 2-3, 1988. there's little question that the Hodgkin and Reed-Sternberg (H and RS) cells and their versions symbolize the malignant inhabitants in Hodgkin's lymphoma; notwithstanding, there's nonetheless a fierce debate as to the potential mobile of starting place of Hand RS cells. a number of the difficulties confounding previous examine into this question have been concerning the trouble or digital impossibility, of acquiring purified populations of Hand RS cells. many of the contemporary development stems from the institution of everlasting telephone traces of Hand RS cells in culture.

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5 a). 3, 5b). Evidently, in L 540 part of chromosome 14, containing genes for TCR alpha, is translocated to the short arm of chromosome 15, where genes for the ribosomal RNA are located (Fig. 6). A second interesting gene translocation in L 540 has been detected by in situ hybridization using a DNA probe from the met oncogene. In addition to the labeling in 7q21 - 31, a chromosome region to which met oncogene has been mapped (Dean et al. 1985), we found an abundance of silver grains on marker chromosome XI (Fig.

8. Idiogram of marker chromosome XI, which can be interpreted as being composed of a chromosome 21 and a segment of a chromosome 7 (7q22-qter). The distribution of silver grains (9/67) in 17 cells is shown 42 C. Fonatsch et al. Fig. 9. Partial metaphase of L 540 after G-banding and Ag. NOR staining. Silver-positive regions in marker chromosomes IX (() and XI (t) are indicated by arrows characterized by two chromosomal rearrangements involving regions which contain active ribosomal DNA. It can be speculated that the spatial connection of genes encoding the alphachain of TCR and met oncogene to active genes for ribosomal RNA provides the control of expression of TCR alpha and/ or met oncogene by rDNA-specific promoter or enhancer sequences.

A Karyotype, showing translocations 1(3;5)(q27/29;q3J) and 1(7;9)(pJ5;q34) as well as a duplication in the long arm of chromosome 1. b Karyotype, showing the same translocation 1(3;5) as in a as well as a translocation of the duplicated Jq to l1q23/ 25 46 C. Fonatsch et al. Table 3. Breakpoints frequently found in LCLs after in vitro treatment and consistently involved in marker formation (pre-)Ieukemias and lymphomas In Agent Breakpoints Tumor type CP lq2l/23 (e)" 17p13 (e)" CML, ANLL, non-HD ANLL, non-HD BLM 1q21/23 (e) 2p23/25 a 3q21/23 3q27/29 (e)" 5rq31 (e) 7q22-36a 8q24 a 9q34a 11q23 (e) CML, ANLL, non-HD non-HD, ANLL ANLL M7 non-HD, ANLL M7 ANLL, MDS MDS, ANLL non-HD CML, ANLL, ALL ANLL M4, M5, MPD, ALL, non-HD ANLL M4, M5b 16q22/24 (e)" CP, activated cyclophosphamide; BLM, bleomycin; (c), clonal aberrations, CML, chronic myelocytic leukemia; ANLL, acute nonlymphocytic leukemia; MDS, myelodysplastic syndromes; MPD, myeloproliferative diseases.

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