Jacopo Meldolesi, Alberto Ciardo, Antonello Villa, Fabio's New Developments in Lipid-Protein Interactions and Receptor PDF

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By Jacopo Meldolesi, Alberto Ciardo, Antonello Villa, Fabio Grohovaz (auth.), K. W. A. Wirtz, L. Packer, J. Å. Gustafsson, A. E. Evangelopoulos, J. P. Changeux (eds.)

A NATO complicated examine Institute on "New advancements in Lipid-Protein Interactions and Receptor functionality" used to be hung on the Island of Spetsai, Greece, from August 16-27, 1992. This Institute was once geared up to collect researchers within the box of membrane association and dynamics with these actively curious about stories on receptor functionality, sign transduction mechanisms and gene rules. 2 shows and discussions focussed at the legislation of intracellular Ca +-levels, at the moment messengers derived from inositol lipids and at the particular phospholipase C isozymes keen on those methods. a huge concentration used to be on G-proteins and the impact of lipid anchors on their functionality. those rules of legislation have been additional mentioned within the context of receptors for acetylcholine, lysophosphatidic acid and low-density lipoproteins. moreover, a number of facets of the genomic legislation of mobilephone development and differentiation by way of transcription components have been awarded. those themes have been positioned into standpoint through discussing the latest advancements in lipid-protein interactions, protein insertion into membranes, membrane lipid association and lipid dynamics as mediated by way of phospholipid move proteins. This booklet provides the content material of the key lectures and a variety of the main appropriate of crucial issues posters. those lawsuits supply a accomplished account awarded throughout the process the Institute. The booklet is meant to make those lawsuits available to a wide audience.

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64, 17069-17077. , and Bussolino, F. (1991) The molecular action of tumor necrosis factor-a. 1. Biochem. 202,3-14. A. (1991) Role of phospholipases in generating lipid second messengers in signal transduction. FASEB 1. 5, 2068-2077. , and Fiers, W. (1993) Tumor necrosis factor cytotoxicity is associated with phospholipase D activation. Eur. 1. Biochem. 212,491-497. A. (1990) Tumor necrosis factor-mediated biological activities involve a G-protein-dependent mechanism. 1. BioI. Resp. Modif. 9, 361-367.

W. Kim, A. Zilberstein, B. K. Kim, J. G. Rhee, PDGF stimulation of inositol phospholipid hydrolysis requires PLC--y 1 phosphorylation on tyrosine residues 783 and 1254, Cell 65:435-441 (1991). D. M. L. Margolis, A. Ullrich, and J. Schlessinger, Presence of SH2 domains of phospholipase Coy 1 enhances substrate phosphorylation by increasing the affinity towards the EGF-receptor, J. Bioi. , in press (1992). C. Vega, C. Cochet, O. P. G. N. Gill, A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C, Mol.

34 A major question which arises is whether PLD is specifically activated upon TNF stimulation or merely the result of cell killing per se. Therefore, we tested the effect of a number of cytotoxic agents, different from TNF, on PLD activity. The agents used included menadione (a synthetic quinone), paraquat (a bipyridyl herbicide), as well as dibromothymoquinone and daunorubicine (both quinone-containing antitumor antibiotics). All compounds killed L929 cells within the same incubation time and to approximately the same extent as TNF (Figure 6).

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